Biology and Depression

When it comes to depression, the schism betweenneurotransmitters might function as "the internal
psychology and psychiatry is basically this: therapistsequivalents" of Penfield's externally applied stimulating
influenced by Freud's psychology see depression as aelectrodes? If so, he says, it "would cause patients to
product of the mind and talk about it in terms of drives,report feelings, recollections and ideas generated not
defenses, regressions, and problems of identificationby conflict, fantasy, or drive derivatives, but by
and self-esteem. Those influenced by biologicalchemical stimuli."
psychiatry see depression as a product of the brain,Kantor's ideas have not yet been substantiated by
caused by shifts that take place among hormones andresearch but his thinking is far from wild, for much that
neurotransmitters. Shephard Kantor, a psychiatrist onhas already been learned points in the same direction.
the faculty of the Columbia University College ofIn the meantime, Kantor stands firm in his conviction
Physicians and Surgeons, looks for ways of bringingthat psychiatrists should learn to understand--and
the two approaches together. Kantor believes theaccept--the chemical nature of mood disorders.
mental "productions" of depressed patients--negativeClearly, childhood events produce inner
thoughts and, in the case of psychotics,experience--feelings and attitudes that stay with us,
hallucinations--come from chemical changes in theaffecting our lives immensely. The question psychiatry
central nervous system and are not psychologicallywrestles with is how these powerfully resonant events
caused. He no longer believes that the crazy thinkinginteract with neurotransmitter deficits to produce shifts
that accompanies depression is triggered by externalin mood state that are sometimes volatile, sometimes
events or is the residue--for example--of childhoodsubtle. There are differences, after all, among all of
interactions with parents. He believes the crazy thinkingus--differences in the amount of trauma or stress we
that accompanies depression is caused by theexperience and in the degree of chemical vulnerability
chemical state itself.we inherit. No one exists in a perfect state of chemical
But what is the effect of childhood trauma? we maybalance. Where, then, should the line be drawn with
ask. Surely it can't be totally unrelated to depression.respect to neurotransmitter deficits? Do they exist in all
Kantor suggests that the mental changes ofwho become mood disordered or only in those
depression may be due to certain sensations andsuffering from severe forms of these illnesses?
memory traces that go back to "the calamities ofThese are some of the important questions being
childhood". Such calamities produce changes inaddressed, currently, in the fields of psychaitry and
neurotransmitter levels or receptor sites, he theorizes.psychology.
And it isn't just childhood trauma that does this.* * *
Emotional wounds at any point along the way mightThis article is excerpted from Colette Dowling's book,
produce similar chemical alterations in the brain.You Mean I Don't Have to Feel this Way?: New Help
Studies with primates show that circuitry linkingfor Depression, Anxiety and Addiction.
structures in the central nervous system is responsibleQuotes:
for perception, memory, and emotion. With this in mind,"Beautifully documented... Dowling backs up her
Kantor says, it isn't such a big jump to imagine how thetheories with facts."
tiniest of biochemical disturbances at any of theseWorking Woman
sites might evoke memories and moods whose origins"This really excellent book deals sensitively and directly
lie in childhood.with culturally imbued fears of biological therapies for
Kantor has another idea. One of the breakthroughs ofemotional disorders."
modern neurology was Wilder Penfield's discovery thatDonald F. Klein, Professor of Psychiatry, Columbia
stimulating certain areas of the brain with electricalUniversity College of Physicians and Surgeons
impulses produces visual and auditory images and"A down-to-eaerth, hopeful, useful--and,from the point
memories. Kantor asks this provocative question: Isn't itof view of this "recovered" depressive--accurate
possible that the signals generated byaccount of how to treat depression.