Abnormal Brain Structure In Schizophrenia

The post-mortem analysis of the brains of patientsBecause glial cells regulate both brain inflammation and
with schizophrenia compared to normal brain showsbrain repair, it is clear that serious mental health
severe dysregulation in the matrix outside of brain cellsproblems involve excessive inflammation with a lack of
that holds them together in key regions of therepair.  Even if the glial cells are trying to make a
subconscious brain associated with learning, memory,repair, something is getting in their way.
and the processing of stress.  The finding is the firstThis study is important to everyone as it is likely that
of its kind and it essentially means that the roads andpart of the decline of nervous system function involves
highways that hold brain cells in position are at least asglial cell interaction with the chondroitin sulfate rich
important as the neurotransmitter status that up to thisstructure of the cellular matrix between brain cells.  It
time has received the lion's share of attention.is likely that any level of mental health issue, ranging
The researchers looked at the chondroitin sulfatefrom ADHD to depression to anxiety as well as nerve
structure of the important matrix between brain cellstransmission problems will have at least as part of their
that enables the actual structure of a brain part. issue the structural integrity of the brain cell matrix,
They focused on two important brain regions, thedirectly affecting synaptic plasticity and overall brain
entorhinal cortex (memory and behavior) and thehealth. 
amygdala (compulsions, anxiety, hostility, stressMost people know that chondroitin sulfates are good
response).  They found that the glial cells expressedfor their joints.  Fewer seem to know they are vital
up to 15 fold normal activity with chondroitin sulfate. for the healthy structure of their arteries.  While this
This means that the brain's of schizophrenic patientsstory is just beginning, they may turn out to be vital to
are in a desperate attempt to repair their cellular matrixmental health!  Certainly, any solution that enables the
and restore brain function – an attempt that whilerestoring of the physical structure of the brain and the
ongoing was clearly not working.  This can beproper structural framework of any one brain part is
concluded by the fact that the physical mass of theselikely to lend to better overall connectivity and fewer
brain areas, compared to controls, was less thanproblems with mental health issues.
normal.