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Audio-Visual Entrainment, History and Physiological Mechanisms - by Dave Siever

Copyright 2006. Reproduction of this and brain to relax, become more malleable
material is allowed as long as it is and open to new healthy thoughts,
unaltered and complete with Mind Alive post-hypnotic suggestions, brainwave
contact information. Reproduction for activity and so on. During AVE, the EMG
marketing purposes is prohibited without and electro-dermal responses fall, finger
permission from Mind Alive Inc. temperature increases and breathing
History becomes smooth and diaphragmatic. These
Clinical reports of flicker stimulation changes reflect a return to homeostasis
appear as far back as the dawn of modern or restabilization, hence the term
medicine. It was at the turn of the 20th dissociation and restabilization (DAR)
century when Pierre Janet, at the (40).
Salpêtrière Hospital in France, reported Figure 9 shows a typical reduction in
that when he had his patients gaze into forearm EMG and Figure 10 shows a typical
the flickering light produced from a increase in finger temperature. Notice
spinning spoked wheel in front of a that restabilization begins after about
kerosene lantern, it lowered their six minutes of AVE, when the user begins
depression, tension and hysteria (34). dissociating. Figure 11 shows
Then, in 1934, Adrian and Matthews normalization of breathing and heart rate
published their results showing that the variability following exposure to AVE at
alpha rhythm could be "driven" above and 7.8 Hz.
below the natural frequency with photic Figure 9. Forearm EMG Levels During AVE
stimulation (1). (Hawes, 2000)
This discovery further propagated dozens *** For the complete article with figures
of small physiological outcome studies on included, please see... ***
the "flicker following response" by many Figure 10. Peripheral Temperature Levels
well respected researchers During AVE (Hawes, 2000)
(4,5,11,20,18,22,43). However no one *** For the complete article with figures
considered the subjective and behavioral included, please see... ***
effects of photic stimulation. Finally in Neurotransmitters
1956, W. Gray Walter published the There is evidence that blood serum levels
results on thousands of test subjects of serotonin, endorphine, and melatonin
comparing flicker stimulation with the rise considerably following 10 Hz.,
subjective emotional feelings it produced white-light AVE (42). Increases in
(46). endorphines reflect increased relaxation
Meanwhile, William Kroger accomplished while increased norepinephrine along with
other important developments in photic a reduction in daytime levels of
stimulation. Kroger was a physician melatonin, indicate increased alertness
investigating why radar operators were (Figure 11).
going into trances in front of their Figure 11. Neurotransmitter Levels
radar sets and of course, leaving the Following AVE (42)
ship or plane at great risk to the enemy. *** For the complete article with figures
He concluded that the rhythmic "blip" of included, please see... ***
the radar was "pulling" the radar Dendritic Growth
operators into a trance state. These There is evidence that stimulating
findings compelled Kroger to team up with neurons with mild electrical stimulation
Sydney Schneider of the Schneider promotes growth of dendrites and
Instrument Company of Ohio to construct dendritic shaft synapses in the cells
and market the first electronic clinical being stimulated (6, 25). However,
photic stimulator, called the "Brainwave studies do not yet exist on the influence
Synchronizer." It comprised of an intense of AVE on dendritic growth, although it
xenon strobe light complete with a is suspected because many people with
rotating dial that could be set to the autism, palsy, stroke and aneurysm (36)
frequencies of the standard four brain have gained significant motor and
wave rhythms. They found the Brainwave cognitive function following a treatment
Synchronizer had powerful hypnotic program of AVE.
qualities and soon published a study on Cerebral Blood Flow
hypnotic induction (24). They also Cerebral blood flow (CBF) is essential
prompted other studies involving hypnotic for good mental health and function.
induction in surgery and dentistry, and SPECT and FMRI imaging of CBF show that
studies of general interest to the hypoperfusion of CBF is associated with
hypnosis profession (38, 31, 29). many forms of mental disorders. CBF
In 1981, my wife, Nancy, and I increases dramatically during AVE (12,
incorporated Comptronic Devices Limited, 39). Figure 18 shows an increase of 28%
with a focus on designing TENS units and in cerebral blood flow within the striate
EMG feedback devices for dental (TMJ) cortex, a primary visual processing area
applications. In 1984, I designed the within the occiput. As an interesting
"Digital Audio-Visual Integration Device" note, maximal CBF occurs at 7.8 Hz, the
(DAVID1), used for hypnotic induction and Schumann Resonance of the earth.
to calm anxiety in performing arts Figure 12. Cerebral Blood Flow at
students at the University of Alberta. Various AVE Repetition Rates (12)
The "light and sound" (L&S) market at *** For the complete article with figures
this time was in its infancy and resided included, please see... ***
primarily within the new age sector. Following Fox and Raichle's study was a
There was little "known" research to whole head PET analysis of visual
support L&S technology, and professionals entrainment at 0, 1, 2, 4, 7, and14 Hz
by and large showed disinterest. Due (32). This study on 19 healthy, elderly
mainly to poorly designed L&S products (mean age=64 years) subjects found that
and a lack of research, about 40 L&S regional cerebral blood flow (rCBF) was
companies have come and gone, most of activated differentially with the:
them during the 1980s and 1990s. However, 1) left anterior cingulate showing
since the time of Adrian and Matthews, a maximal increases in rCBF at 4 Hz.
considerable number of studies have 2) right anterior cingulate showing
verified photic and auditory "driving" of decreases in rCBF with frequency.
the EEG. I have since re-named this 3) left middle temporal gyrus showing
phenomenon as "audio-visual entrainment" increases in rCFB at 1 Hz.
or AVE, as any given frequency of 4) striate cortex showing maximal rCBF at
stimulation that is reflected in brain 7 Hz.
wave activity and observable on an EEG or 5) lateral and inferior visual
QEEG can be entrained. Many more studies association areas showing increases in
on photic or combined audio/photic rCBF with frequency.
stimulation exist than pure audio While there may be benefits to increasing
stimulation studies, however audio-only occipital CBF, there is even greater
stimulation studies have confirmed audio concern regarding conditions involving
entrainment (8) and its effect on calming hypoperfuson of CBF in frontal regions.
masseter muscle tension (30). Frontal disorders include: anxiety,
Physiology of Audio-Visual Entrainment depression, attentional and behavior
In order for entrainment to occur, a disorders, and impaired cognitive
constant, repetitive stimuli of function (2). Figure 13 shows an increase
sufficient strength to "excite" the in frontal CBF recorded on Hershel
thalamus must be present. The thalamus Toomin's "Thinking Cap" (or
then passes the stimuli onto the "Hemoencephalogram") using infra-red
sensory-motor strip, the cortex in light to measure perfusion of CBF. Notice
general and associated processing areas that CBF at FPZ increases by 15% in 10
such as the visual and auditory cortexes. minutes (Toomin, personal communication).
Figure 1 shows the visual pathway with Figure 13 Hemoencephalographic
the retina of both eyes becoming excited Measure of Cerebral Blood Flow During 10
and sending pulses down the optic nerve, Hz AVE
through the optic chiasm, and into the *** For the complete article with figures
lateral geniculate of both thalami. From included, please see... ***
here, the visual signals are passed onto Normalized EEG Activity
the visual and cerebral cortexes for Figure 14 shows a fairly typical brain
further processing. Notice that there is map in 1 Hz bins of a person with mild
very little delay from the onset of the depression and anxiety as shown on the
flash to the response in the optic nerve, Skil database. Notice that alpha is
but a delay of approximately 100 msec slowed and approaching +2SD from the norm
occurs by the time the visual evoked and that some beta frequencies (16-18 Hz)
potential (VEP) is elicited in the visual are high (>1SD) in central frontal areas.
cortex. This delay may be why entrainment Figure 14. Brain Map in 1 Hz Bins of
occurs best at the natural alpha Individual with Depression and Anxiety
frequency -- as 100 msec equates to 10 (SKIL-Eyes Open)
Hz. *** For the complete article with figures
Figure 1. The EEG Photic Stimulation included, please see... ***
Path Following an AVE session of 7.8 Hz., both
*** For the complete article with figures alpha and beta activity are normalized as
included, please see... *** shown below in Figure 15.
Photic entrainment begins its process as Figure 15. Brain Map Following 7.8 Hz AVE
a series of overlapping evoked potentials (SKIL-EO)
(23). Kinney broke down a simple VEP into *** For the complete article with figures
its various components (Figure 2) included, please see... ***
representing the passage of time for 4, Conclusion
8, 12 and 20 Hz. As can be seen, much of In closing, AVE has the ability to
the VEP occurs within 250 msec, quickly and effectively relax people out
correlating to four Hz. The various of high sympathetic activation and
overlapping parts were then vector summed traumatic states of mind, bringing a
into the mathematical VEP and compared return to homeostasis. AVE may be used
with the actual VEPs observed by EEG at alongside hypnotic suggestions on tape/CD
the higher, entrained frequencies, shown or live via a microphone. At the same
in Figure 2. time however, AVE exerts a powerful
Figure 2. EEG Wavelet influence on brain/mind stabilization and
*** For the complete article with figures normalization. At the end of an AVE
included, please see... *** session, the user may realize that he/she
When this mathematical model was compared has not felt so relaxed for years --
with the actual observed EEG of the perhaps not since childhood.
entrained stimuli (Figure 3), a high Footnote:
degree of predictability was observed, 1. For more information, address all
demonstrating that photic entrainment is correspondence to:
indeed a vector summation of VEPs and not David Siever, c/o Mind Alive Inc., 9008 -
a novel neuronal process. 51 Avenue, Edmonton, Alberta, Canada, T6E
Figure 3. EEG VEPs - Vector Addition 5X4
(theoretical) Model vs Observed EEG Toll Free: (800) 661-6463 Fax: (780)
*** For the complete article with figures 461-9551 Web:
included, please see... *** Email: References
By definition, entrainment occurs when an 1) Adrian, E. & Matthews, B. (1934) The
EEG reflects the brain wave frequency Berger rhythm: Potential changes from the
duplicating that of the stimuli, be it occipital lobes in man. Brain, 57,
audio, visual or tactile (41). 355-384.
Entrainment occurs best near one's own 2) Amen, D. (1998). Change your brain,
natural alpha frequency (43, 23). LEDs change your life. New York: Three Rivers
and xenon strobe lights contain much Press.
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or rapid turn-on and turn-off transitions induced by photic stimulation in relation
of the stimuli and these harmonics are to intrinsic alpha activity of the brain
reflected within the EEG. Figure 4 shows in man. Electroencephalography and
a strong and pure entrainment at 12 Hz. Clinical Neurophysiology, 12, 317-326.
The harmonics (small wavelets) seen in 4) Bartley, S. (1934). Relation of
the EEG are a reflection of the actual intensity and duration of brief retinal
harmonics contained within the stimulus. stimulation by light to the electrical
Square wave stimulation is associated response of the optic cortex of the
with an increased risk of seizure (21, rabbit. American Journal of Physiology,
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without harmonics is via sine wave 5) Bartley, S. (1937). Some observations
stimulation in which the stimuli turn on on the organization of the retinal
and turn off in slow, gentle transitions response. American Journal of Physiology,
and do not contain harmonics. (45, 44, 120, 184-189.
35, 41). 6) Beardsley, T. (1999, June). Getting
Figure 4. EEG Showing Photic Entrainment wired. Scientific American, 24-25.
*** For the complete article with figures 7) Brownbeck, T. & Mason, L. (1999).
included, please see... *** Neurotherapy in the treatment of
AVE at 18.5 Hz has also been shown to dissociation. In J. R. Evans, & A.
produce dramatic increases in EEG Arbanel. (Eds.), Introduction to
amplitude at the vertex (14), where it quantitative EEG and neurofeedback (pp
was found that:a) eyes-closed 18.5 Hz. 145-156). San Diego: Academic Press.
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activity by 49%.b) eyes-open auditory J. (1959). Response to clicks from the
entrainment produced increased 18.5 Hz. human brain: Some depth electrographic
EEG activity by 27%.c) eyes-closed observations. Electroencephalography and
auditory entrainment produced increased Clinical Neurophysiology, 12, 479-489.
18.5 Hz EEG activity by 21%.d) 9) Dempsey, E. & Morison, R. (1942). The
eyes-closed AVE produced increased 18.5 interaction of certain spontaneous and
Hz. EEG activity by 38.3%. induced cortical potentials. American
Entrainment primarily shows itself Journal of Physiology, 135, 301-307.
frontally and near the vertex (41). 10) Donker, D., Njio, L., Storm Van
Figure 5 is a QEEG, or "brainmap" from Leewan, W., & Wieneke, G. (1978).
the SKIL (Sterman-Kaiser Imaging Labs) Interhemispheric Relationships of
database, in 1Hz bins showing the Responses to Sine Wave Modulated Light in
frequency distribution of AVE at 7.8 Hz. Normal Subjects and Patients.
The area within the circle at 8Hz shows Encephalography and Clinical
maximal effects of AVE in central, Neurophysiology, 44, 479-489.
frontal and parietal regions (at 10uv in 11) Durup, G. & Fessard, A. (1935).
this case) as referenced with the oval L'electroencephalogramme de l'homme (The
area on the legend. It is through these human electroencephalogram). Annale
effects that AVE has proven effective in Psychologie, 36, 1 -32.
treating depression, anxiety and 12) Fox, P. & Raichle, M. (1985).
attentional disorders. A harmonic is also Stimulus rate determines regional blood
present at 16 Hz. (the circled image), flow in striate cortex. Annals of
which is typical of semi-sine wave (part Neurology, 17, (3), 303-305.
sine/part square wave) stimulation. 13) Fox, P., Raichle, M., Mintun, M., &
Figure 5. Brain Map in 1Hz Bins -- Dence, C. (1988). Nonoxidative glucose
During 7.8 Hz AVE (SKIL-Eyes Closed) consumption during focal physiologic
*** For the complete article with figures neural activity. Science, 241, 462-464.
included, please see... *** 14) Frederick, J., Lubar, J., Rasey, H.,
Body/Mind Effects of Audio-Visual Brim, S., & Blackburn, J. (1999). Effects
Entrainment of 18.5 Hz audiovisual stimulation on EEG
We conceptualize AVE as achieving its amplitude at the vertex. Journal of
effects through several mechanisms at Neurotherapy, 3 (3), 23-27.
once (40). These include: 15) Glista, M.D., Frank, M. D., & Tracy,
1) dissociation / hypnotic induction, M. D. (1983). Video games and seizures.
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4) altered cerebral blood flow, and driving and altered states of
5) normalized EEG activity. consciousness: An exploratory study.
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where feelings, memories and physical 17) Goldberger, L. (1982). Sensory
sensations are kept apart from other deprivation and overload. Handbook of
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disruption in integrated functioning (1938). L'action d'une excitation
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On the other hand, dissociation occurs 1217-1220.
when we meditate, exercise, read a good 19) Hear, J. (1971). Field dependency in
book, take in a movie or enjoy a sporting relation to altered states of
event, because we get drawn into the consciousness produced by
present moment and dissociate from all of sensory-overload. Perception and Motor
our daily hassles, worries, anxieties and Skills, 33, 192-194.
the resulting unhealthy mental chatter. 20) Jasper, H. H. (1936). Cortical
Several techniques such as dot staring excitatory state and synchronism in the
and stimulus depression have been shown control of bioelectric autonomous
to induce dissociation (26). Audio rhythms. Cold Spring Harbor Symposia in
dissociation analgesia using white noise Quantitative Biology, 4, 32-338.
has been shown to effectively increase 21) Joyce, M. & Siever, D. (2000).
pain threshold and pain tolerance during Audio-visual entrainment program as a
a dental procedure (33). treatment for behavior disorders in a
Regardless of the activity, this type of school setting. Journal of Neurotherapy,
dissociation reduces our weekly stress 4 (2) 9-25.
load, whether we are aware of it or not. 22) Jung, R. (1939). Das
In essence, when we focus on something, Elektroencephalogram und seine klinische
we dissociate from other things. The Anwendung.(The electroencephalogram and
saying, "a change is as good as a rest," its clinical application). Nervenarzt,
has much more truth to it than initially 12, 569-591.
meets the eye (40). 23) Kinney, J. A., McKay, C., Mensch, A.,
The first study on dissociation induced & Luria, S. (1973). Visual evoked
via entrainment involved hypnotic responses elicited by rapid stimulation.
induction and found that photic Encephalography and Clinical
stimulation at alpha frequencies could Neurophysiology, 34, 7-13.
easily put subjects into hypnotic trances 24) Kroger, W. S. & Schneider, S. A.
(24, 29). Figure 6 shows the results of (1959). An electronic aid for hypnotic
Kroger and Schneider's study in which induction: A preliminary report.
nearly 80% of the participants in the International Journal of Clinical and
study were in a hypnotic trance within Experimental Hypnosis, 7, 93-98.
six minutes of photic entrainment. 25) Lee, K., Schottler, F., Oliver, M., &
Figure 6. Photic Stimulation Induction Lynch, G. (1980). Brief bursts of
of Hypnotic Trance (24) high-frequency stimulation produce two
*** For the complete article with figures types of structural change in rat
included, please see... *** hippocampus. Journal of Neurophysiology,
Psychologists have been looking for ways 44 (2), 247-258.
to dissociate their clients as a part of 26) Leonard, K., Telch, M., & Harrington,
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dissociation using AVE delivered by the laboratory: A comparison of strategies.
DAVID1 was found to be more effective Behaviour Research and Therapy, 37,
than dot staring or stimulus deprivation 49-61.
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Figure 7. AVE Induced Dissociation (26) P. (2000). Fear response to dissociation
*** For the complete article with figures challenge. Anxiety, Stress and Coping,
included, please see... *** 13, 355-369.
Furthermore, Leonard completed a second 28) Lipowsky, Z. (1975). Sensory and
study with people who experience information inputs over-load: behavioral
dissociative anxiety (27). People with effects. Comprehensive Psychiatry, 16,
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a sense of control in their lives and 29) Lewerenz, C. (1963). A factual report
become anxious or panicky when they on the brain wave synchronizer. Hypnosis
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Acute Dissociation Inventory (ADI) is a (1981). The application of
35-item self-report scale (26). It audiostimulation and electromyographic
assesses dissociative sensations biofeedback to bruxism and myofascial
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when dissociating, by using a DAVID 21-24.
Paradise HemistepTM alpha session. As 32) Mentis, M., Alexander, G., Grady, C.,
expected, the participants' anxiety Krasuski, J., Pietrini, P., Strassburger,
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of the AVE session. The surprise, S. (1997). Frequency variation of a
however, was that their heart rate pattern-flash visual stimulus during PET
actually decreased, contrary to normal differentially activates brain from
anxiety reactions (Figure 8). With the striate through frontal cortex.
ability to clinically dissociate these Neuroimage, 5, 116-128.
people, yet simultaneously calm them down 33) Morosko, T. & Simmons, F., (1966).
somatically, AVE can be used as a The effect of audio-analgesia on pain
desensitization tool for reducing threshold and pain tolerance. Journal of
dissociative anxiety. Dental Research, Vol 45, 1608-1617.
Figure 8. Dissociative Anxiety and 34) Pieron, H. (1982). Melanges
Somatic Arousal (27) dedicated to Monsieur Pierre Janet. Acta
*** For the complete article with figures Psychiatrica Belgica, 1, 7-112).
included, please see... *** 35) Regan, D. (1966). Some
A dissociative mindstate or hypnotic characteristics of average steady-state
trance may be described in terms of an and transient responses evoked by
altered state of consciousness (ASC) in modulated light. Electroencephalogy and
which the subject (or an independent Clinical Neurophysiology, 20, 238-248.
observer of the subject) observes a 36) Russell, H. (1996). Entrainment
qualitative shift in the normal pattern combined with multimodal rehabilitation
of mental functioning (16). ASCs produced of a 43-year-old severely impaired
via overstimulation also occur when a postaneurysm patient. Biofeedback and
person is bombarded with higher than Self Regulation, 21, 4.
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in more than one sensory modality (19, January). Epileptic seizure induced by a
28, 17). Glicksohn studied photic product marketed as a "Brainwave
entrainment and the ASCs produced. He Synchronizer." Neurology, 44, 180.
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photic entrainment. They all described a in anaesthesiology. Illinois Medical
wide variety of reactions to the Journal, 39-42.
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incredible imagery consisting of items Fein, G., Hugg, J., Biggins, C., &
they had seen before in their lives, Weiner, M. (1992). Effect of photic
intertwined with geometrical patterns stimulation on human visual cortex
while others reported no visual changes lactate and phosphates using 1H and 31P
at all. At the end of the study, magnetic resonance spectroscopy. Journal
Glicksohn concluded that: of Cerebral Blood Flow and Metabolism, 12
1) It is the increase in alpha activity (4), 584-592.
created by photic driving, and not the 40) Siever, D. (2000). The rediscovery
natural alpha activity itself, that is of audio-visual entrainment technology.
conducive to an ASC. Unpublished manuscript.
2) The appearance of visual imagery is 41) Siever, D. (2002). New technology for
neither necessary nor all that is attention and learning. Unpublished
invo